Contraindicated (1)pentobarbital will reduce the level or impact of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can reduce panobinostat ranges by ~70% and result in remedy failu